IL-11 is multifunctional cytokine whose physiological freetress deep twist crochet hair 14 inch role in the lungs during pulmonary tuberculosis (TB) is poorly understood.Here, using in vivo administration of specific antibodies against IL-11, we demonstrate for the first time that blocking IL-11 diminishes histopathology and neutrophilic infiltration of the lung tissue in TB-infected genetically susceptible mice.Antibody treatment decreased the pulmonary levels of IL-11 and other key inflammatory cytokines not belonging to the Th1 axis, and down-regulated IL-11 mRNA expression.This suggests the existence of a positive feedback loop at the transcriptional level, which is further supported by up-regulation of IL-11 mRNA expression in the presence of rIL-11 in in vitro cultures of lung cells.These findings imply a pathogenic role for IL-11 during ezall fly spray the early phase of Mycobacterium tuberculosis-triggered disease in a genetically susceptible host.